Genotoxicity is the study of the effect of chemicals on nucleic acid stability.
The branch of Genetic Toxicology has evolved in response to the concern that certain chemicals have been found to induce mutations in various experimental systems. These chemicals are likely to affect the incidence of heritable disease in man and/or be potentially carcinogenic. Various tests based on diversified mutagenic effects have been recommended by OECD, as well as OPPTS (OCPSS), for evaluation of mutagenic potential of the test chemicals.
JRF Global has over three decades of expertise and experience, well honed under the global scientists of repute in genotoxicity. JRF has a well organised, purpose-built facility to conduct all the standard in vivo and in vitro genetic toxicology assays. Each assay uses protocols that comply with harmonised international guidelines.
Genetic Toxicology
In Vitro
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Bacterial Reverse Mutation Test (Ames test) using Salmonella typhimurium and E. coli WP2 uvrA
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In Vitro Mammalian Chromosome Aberration Test using Chinese Hamster Ovary - K1 cell line
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In Vitro Mammalian Chromosome Aberration Test using Human Peripheral Blood Lymphocytes
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In Vitro Mammalian Cell Gene Mutation Test (HPRT assay) using Chinese Hamster Ovary-K1 cell line
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In Vitro micronucleus test using Human Lymphocytes from Healthy Donor
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In Vitro micronucleus test using CHO-K1 cell line
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In Vitro Dermal Absorption using Human and Rat skin
In Vivo
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In Vivo Mammalian Erythrocyte Micronucleus Test in Mice/Rat (With and without toxicokinetic)
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In Vivo Mammalian Bone Marrow Chromosome Aberration Test in Mice/Rat (With and without toxicokinetic)
Services available at following locations: